促分裂原活化蛋白激酶激酶3 (phospho Ser218)多克隆抗体

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产品英文名称	MEK-3 (phospho Ser218) Polyclonal Antibody
免疫原	合成多肽：人源蛋白MEK-3，磷酸化多肽，中心氨基酸为S189.
宿主	兔
反应性	人, 大鼠, 小鼠
应用	ELISA, IHC-P, WB
实验建议	最佳的工作稀释比例需要客户摸索优化。建议的起始尝试的稀释比为：WB：1:500-1:2000，IHC-p：1:100-1:300，ELISA：1:5000。尚未在其他应用中测试。
克隆性	多克隆
纯化工艺	使用表位特异性的免疫原，通过亲和层析，从兔抗血清中亲和纯化抗体。

产品形式	液体溶液
浓度	1 mg/ml
储存缓冲液	含有50％甘油，0.5％BSA和0.02％叠氮化钠的PBS缓冲液。
保存建议	自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件	蓝冰运输
警告	本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。

背景	Mitogen-activated protein kinase 3 encoded by MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. Mitogen-activated protein kinase 3 is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. Mitogen-activated protein kinase 3 can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of Mitogen-activated protein kinase 3 is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MAP2K3.
基因ID	5606
别名	MAP2K3; MEK3; MKK3; PRKMK3; SKK2; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2
其它	该抗体可检测内源蛋白
蛋白质ID	P46734